Use the no form of the ipv6 route command to remove a static route.
device# show ipv6 route 2225::/32 vrf blue IPv6 Routing Table for VRF "blue" Total number of IPv6 routes: 10 '*' denotes best ucast next-hop '[x/y]' denotes [preference/metric] 2225::/32 *via 1200:3::1:2, Eth 2/47, [1/1], 0m5s, static, tag 0 device# show ipv6 route 2225::/32 vrf blue Total number of IP routes: 0 device#
device# configure terminal device(config)# vrf blue device(config-vrf-blue)# address-family ipv6 unicast device(vrf-blue-ipv6-unicast)#
device(vrf-blue-ipv6-unicast)# no ipv6 route 2225::/32 1200:3::1:2
device# show ipv6 route 2225::/32 vrf blue Total number of IP routes: 0 device#