You can enable ARP Guard on a physical interface or a port-channel.
device# configure terminal
device(config)# mac access-list extended arp_guard_enable_1
device(conf-macl-ext)# permit host 0014.2211.1111 any vlan 100 arp arp-guard device(conf-macl-ext)# permit host 0014.2211.1112 any vlan 101 arp arp-guard device(conf-macl-ext)# deny any any arp device(conf-macl-ext)# permit any any
device(conf)# interface ethernet 1/2
device(conf-if-eth-1/2)# switchport
device(conf-if-eth-1/2)# mac access-group arp_guard_enable_1 in
device# configure terminal device(config)# mac access-list extended arp_guard_enable_1 device(conf-macl-ext)# permit host 0014.2211.1111 any vlan 100 arp arp-guard device(conf-macl-ext)# permit host 0014.2211.1112 any vlan 101 arp arp-guard device(conf-macl-ext)# deny any any arp device(conf-macl-ext)# permit any any device(conf)# interface ethernet 1/2 device(conf-if-eth-1/2)# switchport device(conf-if-eth-1/2)# mac access-group arp_guard_enable_1 in