Use the no form of the ipv6 route command to remove a static route.
device# show ipv6 route IPv6 Routing Table for VRF "default-vrf" Total number of IPv6 routes: 11 '*' denotes best ucast next-hop '[x/y]' denotes [preference/metric] 1200:1201::/64, attached *via ::, Eth 2/45, [0/0], 45m29s, direct, tag 0 1200:1201::1:1/128, attached *via ::, Eth 2/45, [0/0], 45m29s, local, tag 0 1200:1202::/64, attached *via ::, Ve 2, [0/0], 45m26s, direct, tag 0 1200:1202::1:1/128, attached *via ::, Ve 2, [0/0], 45m26s, local, tag 0 2221::/32 *via 1200:1201::1:2, Eth 2/45, [100/10], 11m41s, static, tag 300 2222::/48 *via fe80::205:33ff:fee6:a531, Eth 2/45, [1/1], 43m44s, static, tag 0 2222::1/128 *via fe80::205:33ff:fee6:a531, Eth 2/45, [110/1], 0m7s, ospfv3, intra, tag 0 2223::/64 *via 1200:1202::1:2, Ve 2, [1/1], 3m45s, static, tag 0 2224::1/128 *via fe80::205:33ff:fee6:a501, Ve 2, [1/1], 43m41s, static, tag 0 fe80::/10, attached *via ::, , [0/0], 6h30m, local, tag 0 ff00::/8, attached *via ::, Null0, [0/0], 6h30m, local, tag 0
device# show ipv6 route static IPv6 Configured Static Routes for VRF "default-vrf" 3002:7::/64-> 1200:3::1:2 preference: 1 nh_vrf (default-vrf) 3002:9::/64-> 1200:4::1:2 preference: 1 nh_vrf (default-vrf)
device# configure terminal
device(config)# no ipv6 route 2224::1/128 fe80::205:33ff:fee6:a501 ve 2